Curmerol is a bioactive fraction specifically developed by DLBS, derived from the Indonesian indigenous herb Curcuma domestica rhizome, commonly known as Curcuma longa or kunyit. This herb is widely used in traditional Indonesian medicine for its numerous health benefits, particularly in managing cholesterol levels. Additionally, it is believed to possess anti-inflammatory and antioxidant properties. Due to its beneficial composition and effects, Curmerol is highly valued for its ability to help manage cholesterol levels and support overall cardiovascular health.
Product Overview
Botanical origin
Curcuma domestica rhizome
Type of extract
Dry extract
Analytical markers: Curcuminoids
Product Specification
1. Premium Quality and Standardization
Curmerol is a standardized extract crafted to meet stringent quality specifications.
2. Manufactured in a Certified Facility
Produced in a facility with GMP, CPOTB, IEBA and ISO22000 certifications, ensuring top-tier quality.
Guaranteed Halal through the implementation of the Halal Assurance System.
3. Proven Safety Through Rigorous Studies
Acute and subchronic toxicity studies exhibited DLBS2411 as a practically non-toxic substance, indicated by the LD50 value greater than 5 g/kg body weight. Furthermore, a 90 days dose of DLBS2411 up to 1000 mg/kg body weight revealed its safety with no changes in behaviour or motor activity observed, and histopathological examinations revealed no clinically significant abnormalities in body organs.
4. Proven Benefits through Pre-clinical Study
In vitro studies have shown Curmerol effectiveness in managing cholesterol levels. Its potential mechanism of action involves cholesterol metabolism, cholesteryl ester transfer protein (CETP) and HMG-CoA reductase, LDL-receptor activity, and CYP7A1 activity which leads to reduced blood cholesterol levels and promotes cholesterol utilization. Additionally, the anti-inflammatory and antioxidant properties of C. domestica may also play a crucial role in supporting cardiovascular health.
In vivo studies in hypercholesterolemia-induced rats showed Curmerol significantly reduced total cholesterol, triglycerides, and LDL levels. Total cholesterol levels returned to baseline after six weeks of Curmerol treatment. Therefore, Curmerol is a potentially effective treatment for managing cholesterol based on the studies concluded.
Key Feature of the Product
Curcuma domestica has been extensively studied for its anti-inflammatory properties, and antioxidant effects. The anti-inflammatory and antioxidant effects may help manage cholesterol levels and support overall cardiovascular health. Additionally, Curcuma domestica also helps regulate lipid metabolism by reducing total cholesterol, triglycerides, and LDL cholesterol levels while increasing HDL cholesterol levels.
Empirical Benefit
Curcuma domestica has been used in Indonesian traditional medicine for various purposes, such as reducing inflammation, improving digestion, treating digestive issues, promoting wound healing, addressing minor cuts and bruises. It is also believed to help the body fight oxidative stress and support the immune system. It is also believed to promote liver health in traditional practices, with some using it to detoxify the liver and improve its function.
Proven effective for treating gastrointestinal issues based on pre-clinical study data
Curmerol which contains the Curcuma domestica rhizome has shown the ability to inhibit lipid accumulation and lower total cholesterol levels. Curcuma domestica also exhibit anti-inflammatory and antioxidant properties by inhibiting enzymes like cyclooxygenase-2 (COX-2), lipoxygenase (LOX), and inducible nitric oxide synthase (iNOS). Besides that, C. domestica also reduces oxidative stress and lipid peroxidation, which may help diminish the formation of atherogenic particles, thereby supporting cardiovascular health.
Health Benefit
Store at room temperature (≤ 30°C), in a tight container, protect from direct sunlight.
Storage Conditions
Product information of HerbaWELL Kolesdex
Vali Musazadeh, et al. Curcumin as a novel approach in improving lipid profile: An umbrella meta-analysis. Nutrition, Metabolism and Cardiovascular Diseases, Volume 32, Issue 11, 2022, Pages 2493-2504. https://doi.org/10.1016/j.numecd.2022.07.021.