Phycentin is a standardized extract developed by DLBS containing the herb of Phyllanthus niruri (meniran) and Centella asiatica (pegagan). In traditional Indonesian medicine, both Phyllanthus niruri and Centella asiatica are used for improving cognitive function. These herbs are valued for their potential to help with mental fatigue, enhance memory, and reduce stress, which contributes to better cognitive health. Phycentin has been proven to improve cognitive function through neuroprotective and antioxidant mechanisms.
Product Overview
Botanical origin
Phyllanthus niruri herba
Centella asiatica herba
Type of extract
Dry extract
Analytical markers: Madecassoside and Rutin
Product Specification
1. Premium Quality and Standardization
Phycentin is a standardized extract crafted to meet quality specifications.
2. Manufactured in a Certified Facility
Produced in a facility with GMP, CPOTB, IEBA and ISO22000 certifications, ensuring top-tier quality.
Guaranteed Halal through the implementation of the Halal Assurance System.
3. Proven Safety Through Rigorous Studies
Acute and subchronic toxicity studies exhibited Phycentin as a practically non-toxic substance, indicated by the LD50 value greater than 5 g/kg body weight. Furthermore, a 90 days dose of Phycentin up to 1000 mg/kg body weight revealed its safety with no changes in the hematology and urine profile, or abnormalities in animal organs.
Key Feature of the Product
Empirical benefit
Phyllanthus niruri is empirically used for liver health and detoxification, kidney health and urinary tract issues, anti-inflammatory and pain relief, digestive health, boost immunity, and treat infections, among other uses. Centella asiatica is used for improving cognitive function and memory, promoting skin health and wound healing, reducing inflammation, improving circulatory and cardiovascular health, and supporting digestion. This herbal combination in Phycentin has been empirically proven to be an effective remedy to improve cognitive function.
Health benefits of each herbal composition of Phycentin
Phyllanthus niruri is widely used in traditional medicine for a variety of health conditions. It is considered to have strong antioxidant properties, which help protect cells from damage caused by free radicals. In Phycentin, Phyllanthus niruri contributes to boost the immune system due to its properties as an immunomodulator.
Centella asiatica has a broad range of traditional uses in Indonesian medicine. In Ayurvedic medicine, Centella asiatica is widely used as a brain tonic to improve neural function, learning, and memory. In Phycentin, Centella asiatica is effective in enhancing memory function due to its properties as a brain tonic.
Proven effective for improving cognitive function based on literature studies data
Phyllanthus niruri has antioxidant flavonoid that can be used as free-radical scavengers.3 Based on literature study in rats, it demonstrated the ability of Phyllanthus niruri extract to mitigate the sensorimotor and cognitive deficit due to its flavonoid constituent. Another study in mice also shows its ability to improve memory and cognitive function caused by brain damage due to oxidative damage induced by 10% ethanol.
Centella asiatica demonstrates remarkable cognitive, neurotropic and neuroprotective effects. Based on literature study in rats, it showed that the ability of C. asiatica to affect brain functions, as well as its efficacy as a brain tonic, probably through the action of active metabolites that may reach the brain and induce the positive modulations. Other study in rats also shown the anticholinergic and antioxidant effects of Centella asiatica extract due to the presence of Asiatic acid and Madecassic acid, which not only provide neuroprotection against age-associated cognitive decline but also improve the cognitive function. The effects also confirmed by clinical study that shows the administration of Centella asiatica for 20 weeks has an effect on increasing semantic fluency and visual memory in elderly women with dementia.
Based on the literature studies above, it can be concluded that combination of Phyllanthus niruri and Centella asiatica are effective in improving cognitive function.
Health Benefit
Store at room temperature (≤ 30°C), in a tight container, protect from direct sunlight.
Storage Conditions
Product information of HerbaWELL Memodex
Ambali, Suleiman & Makinde, Annas & Muftau, Shittu & Adeniyi, Stephen & Mowuogwu, Favour. (2012). Alleviating Effect of Phyllanthus niruri on Sensorimotor and Cognitive Changes Induced by Subacute Chlorpyrifos Exposure in Wistar Rats. American Journal of Medicine and Medical Sciences. 2. 50-58. 10.5923/j.ajmms.20120203.05.
Pratiwi, D. S. 2013. Pengaruh Pemberian Fraksi Etil Asetat Herba Meniran (Phyllanthus niruri L.) terhadap Peningkatan Memori dan Fungsi Kognitif pada Mencit Galur Balb/c berdasarkan Passive Avoidance Test. Skripsi: Universitas Gajah Mada. Source: https://etd.repository.ugm.ac.id/penelitian/detail/67798
Gray NE, Alcazar Magana A, Lak P, Wright KM, Quinn J, Stevens JF, Maier CS, Soumyanath A. Centella asiatica - Phytochemistry and mechanisms of neuroprotection and cognitive enhancement. Phytochem Rev. 2018 Feb;17(1):161-194. doi: 10.1007/s11101-017-9528-y. Epub 2017 Sep 20. PMID: 31736679; PMCID: PMC6857646.
Sbrini G, Brivio P, Fumagalli M, Giavarini F, Caruso D, Racagni G, Dell'Agli M, Sangiovanni E, Calabrese F. Centella asiatica L. Phytosome Improves Cognitive Performance by Promoting Bdnf Expression in Rat Prefrontal Cortex. Nutrients. 2020 Jan 29;12(2):355. doi: 10.3390/nu12020355. PMID: 32013132; PMCID: PMC7071263.
Zeba Firdaus, et al. Centella asiatica improves memory and executive function in middle-aged rats by controlling oxidative stress and cholinergic transmission. Journal of Ethnopharmacology, Volume 325, 2024, 117888, ISSN 0378-8741. https://doi.org/10.1016/j.jep.2024.117888.
Fitriana, L. A., et al. 2021. Twenty weeks of Centella asiatica improved cognitive function of women elderly with dementia. IOP Conference Series: Earth and Environmental Science. doi: 10.1088/1755-1315/755/1/012064