Nigella sativa, Phaleria macrocarpa
HerbaCOLD
HerbaCOLD is a herbal product containing Silfamin, a bioactive fraction from a combination of two unique Indonesian herbals, Nigella sativa (Jintan Hitam) and Phaleria macrocarpa (Mahkota Dewa). Preclinical studies of Silfamin have shown its ability to stimulate the immune system. Moreover, anti-inflammation and antipyretic studies have been conducted on Silfamin. With these effects, HerbaCOLD can treat colds accompanied by a sore throat. Acute and subchronic toxicity studies of Silfamin proved the safety of this bioactive fraction.
HerbaCOLD contains a precisely formulated dose of 300 mg of Silfamin in film-coated caplet forms.
A Brief Introduction to Our Product
As an immunomodulator, Silfamin can increase macrophage phagocytotic activity, stimulate interferon-gamma synthesis, promote lymphocyte proliferation, and boost both humoral and cellular immune response. As an immunostimulant agent, Silfamin strengthens the body's immune system when combating a cold.
Traditionally, both Nigella sativa and Phaleria macrocarpa have been used for their anti-inflammatory properties. The most abundant and active component of N. sativa is thymoquinone, which is believed to exert its anti-inflammatory effect by inhibiting 5-lipooxygenase and leukotriene synthesis. Meanwhile, the compounds that play a role in P. macrocarpa as anti-inflammatories are flavonoids. Flavonoid has been identified for its potential to inhibit COX. Thus, it inhibits the formation of PGE.
Moreover, the in-vivo study also provides evidence for the antipyretic properties of Silfamin, which are important for treating fever associated with colds.
Product Functions
Preclinical studies of Silfamin have demonstrated its ability in stimulating the immune system. These studies showed that this bioactive fraction promoted the elimination rate of carbon particles, increased the phagocytic index, organ mass index, and body weight, enhanced peritoneal macrophage activity, specific immune response, production of IFN gamma, and splenocyte proliferation in mice. In vitro studies also indicated that Silfamin can enhance IL-1β gene expression, contributing to the improvement of the immune system.
An in vivo study using the carrageenan-induced paw edema method in mice further demonstrated the anti-inflammatory effect of Silfamin. Treatment with Silfamin significantly reduced edema, indicating its anti-inflammatory activity.
In addition, Silfamin has been studied for its antipyretic effects through in vivo tests on mice. The results of this study showed a decrease in the temperature of the test animals, induced by peptone, after receiving Silfamin.
The safety properties of HerbaCOLD have been extensively studied. Acute and subchronic toxicity studies exhibited Silfamin to be a non-toxic substance, as indicated by the LD50 value greater than 15 g/kg body weight.
Furthermore, the repeated dosing of Silfamin for 90 days did not show toxicity to the organs, and blood biochemistry, as well as influence behavior and activity.
Insights and Discoveries
Dosage Instructions
1 film-coated caplet, 2 times daily.
Contraindications
Patients who have hypersensitivity toward this component.
Side Effects
No side effects have been reported. It is considered safe if taken at recommended dosage.
Recommendations for Safe Administration and Use of Our Product
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Our Patent Rights
Store at a temperature below 30°C, in a dry place, and protect from direct sunlight.
Kept out of reach of children.
Storage Conditions
HerbaCOLD has been registered and is available in Singapore
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Anti-Inflammation Effects of Bioactive Fraction DLBS0533 Containing Phaleria Macrocarpa and Nigella Sativa on Animal Model (2015)