DLBS2411 is a bioactive fraction derived from the bark of Cinnamomum burmannii, commonly known as kayu manis. It is highly valued in traditional Indonesian medicine for its purported health benefits. It is believed to have anti-inflammatory, antioxidant, and antimicrobial properties, and is often used to treat digestive issues. DLBS2411 is valued for its ability to treat peptic ulcers, GERD, and support overall gastrointestinal health.
Product Overview
Botanical origin
Cinnamomum burmannii cortex
Type of extract
Dry extract
Concentrated extract
Analytical markers: Proanthocyanidin A-trimer and Total Phenolic Compounds
Product Specification
1. Premium Quality and Standardization
DLBS2411 is a standardized extract that has been through a fractionation process to reduce its coumarin content to below 0.025% and is made to meet quality specifications.
The product is premium quality as it adheres to regulatory requirements in various countries, including a limited coumarin content regulated by European laws.
2. Manufactured in a Certified Facility
Produced in a facility with GMP, CPOTB, IEBA and ISO22000 certifications, ensuring top-tier quality.
Guaranteed Halal through the implementation of the Halal Assurance System.
Manufactured in Different Forms of Extract
DLBS2411 is available as a dry and concentrated extract, which is designed to provide flexible options to meet individual preferences and needs.
3. Proven Safety Through Rigorous Studies
Acute and subchronic toxicity studies exhibited DLBS2411 as a non-toxic substance, indicated by the LD50 value greater than 15 g/kg body weight. Furthermore, a 90 days repeated dose of DLBS2411 revealed no changes in the hematology or abnormalities in animal organs.
Chronic toxicity studies exhibited DLBS2411 is safe for long term use.
The results of teratogenicity studies, which assess safety during pregnancy, indicate DLBS2411 as a non-teratogenic substance.
4. Proven Benefits through Pre-clinical Study
In vitro studies have shown DLBS2411 protective effects on the gastric and colon mucosa through several pathways. Its mechanism of action involves decreasing the level of H+/K+ ATPase mRNA expression, the synthesis of gastric and colon mucus by elevating the phosphorylation of IKKα and activating NF-κB, which promotes the transcription of MUC5AC and COX-2, leading to an increase in nitric oxide (NO) production. These studies suggest that DLBS2411 could potentially be used to treat gastrointestinal issues.
In vivo studies have also confirmed treatment with DLBS2411 showing its gastroprotective properties and also effectively protected the stomach lining.
Pharmacodynamic studies demonstrate that DLBS2411 in acetic acid-induced rats positively demonstrates a curative activity for acetic-induced gastric ulcer.
DLBS2411 is also beneficial because of its potent antioxidant activity.
Key Feature of the Product
Empirical Benefit
Cinnamomum burmannii has been empirically proven to be an effective remedy for gastrointestinal tract issues.
Health Benefit
DLBS2411 which contains the Cinnamomum burmannii cortex, is used to treat digestive issues such as peptic ulcers, especially under various pH conditions, including low gastric pH. This suggests its potential as a pharmacological agent for managing hyperacidity and reducing gastric ulceration. Furthermore, DLBS2411 is noted for its potent antioxidant activity, adding to its therapeutic value in clinical settings.
Proven effective for treating gastrointestinal issues based on pre-clinical study data
In vivo studies have shown experiments involving indomethacin and ethanol-induced rats, treatment with DLBS2411 resulted in a reduction in the number of petechiae, suggesting its gastroprotective properties. Furthermore, DLBS2411 also effectively protected the stomach lining. In other studies, DLBS2411 in acetic acid-induced rats showed a comparable effect to omeprazole and sucralfate in reducing ulcer severity, as shown by histopathological results. These results suggest that DLBS2411 is effectively proven to treat gastrointestinal issues and it is also beneficial because of its potent antioxidant activity.
Health Benefit
Store at room temperature (≤ 30°C), in a tight container, protect from direct sunlight.
Storage Conditions
Product information of Redacid